Sulphonamide, Sulphates and Ordinary Diet. A Clinical Investigation into the Effects of Their Simultaneous Administration

In 1936 the publication of the work of Colebrook and Kenny and others on the action of prontosil caused the English-speaking medical world to adopt the new chemotherapy with enthusiasm. That this enthusiasm was sometimes untempered by caution can be judged by the large number of reports published in 1937 describing toxic complications following the use of sulphonamide*. Among these complications sulphgemoglobinaemia figured prominently though not the most frequently; that it is still most readily brought to mind may be due to two factors. The first is the mistaken idea (which dies hard) that cyanosis indicates sulphsemoglobinsemia, and the second is that the restrictions that have been